Lab Publication - Cancer Genetics

Genomic and transcriptomic somatic alterations of hepatocellular carcinoma in non-cirrhotic livers

Highlights

  • Non-cirrhotic HCC genomically resembles cirrhotic HCC
  • Comprehensive genome- and transcriptome-wide profiling allows detection of novel structural variants, fusions, and undiagnosed viral infections
  • NR1H4 fusions may represent a novel mechanism for tumorigenesis in HCC
  • Non-cirrhotic HCC is characterized by genotoxic mutational signatures and dysregulated liver metabolism
  • Clinical history and comprehensive omic profiling incompletely explain underlying etiologies for non-cirrhotic HCC highlighting the need for further research

Read the paper: Cancer Genetics


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